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目的总结BCSG1、Cox-2、突变型p53蛋白表达与乳腺癌临床病理因素相关性,致力于寻找改善乳腺癌患者临床指征的方案。方法回顾性分析2013年1月-2015年1月医院保存的100例乳腺癌完整手术标本资料。以免疫组化法对BCSG1、Cox-2、突变型p53蛋白表达等进行深入检测,同时观察各项指标与乳腺癌临床病理因素相关性。结果 BCSG1表达与临床分期、组织学分级以及淋巴结转移呈正相关,而与组织学类型、激素受体(ER)、肿瘤大小、孕激素受体(PR)以及月经无直接性关系(P>0.05);同时,Cox-2阳性病患有69例(69.00%),且其蛋白表达和病患激素受体情况、年龄、临床分期、肿瘤大小以及淋巴结的转移无直接性关系(P>0.05),但与C-erb B-2基因蛋白表达之间则具有一定关系(P<0.05)。此外,入选标本中有47例突变型p53蛋白,其阳性的表达率是47.00%,与病患激素受体情况、年龄以及临床分期等方面无直接性关系(P>0.05),但与C-erb B-2基因蛋白表达、肿瘤大小以及淋巴结的转移有一定关系(P<0.05)。结论基于乳腺癌病患而言,其疾病发展、疾病转移以及疾病的侵袭性和BCSG1、Cox-2、突变型p53蛋白表达表现出密切关系,因此可将其视作诊断的标志物。
Objective To summarize the correlation between the expression of BCSG1, Cox-2 and mutant p53 protein and the clinicopathological factors in breast cancer, and to find a solution to improve the clinical indications in patients with breast cancer. Methods The data of 100 complete breast cancer specimens preserved in the hospital from January 2013 to January 2015 were retrospectively analyzed. The expression of BCSG1, Cox-2 and mutant p53 protein were detected by immunohistochemistry, and the correlation between each index and clinicopathological factors was also observed. Results The expression of BCSG1 was positively correlated with clinical stage, histological grade and lymph node metastasis, but not with the histological type, hormone receptor (ER), tumor size, progesterone receptor (PR) and menstrual cycle (P> 0.05) 69 cases (69.00%) were positive for Cox-2, and there was no direct relationship between the protein expression and the status of hormone receptor, age, clinical stage, tumor size and lymph node metastasis (P> 0.05) However, there was a relationship between the expression of C-erb B-2 gene and protein (P <0.05). In addition, there are 47 cases of mutant p53 protein in the selected specimens, the positive rate was 47.00%, and the patient’s hormone receptor status, age and clinical stage, there is no direct relationship (P> 0.05) erb B-2 gene protein expression, tumor size and lymph node metastasis (P <0.05). Conclusion Breast cancer patients have a close relationship with their disease progression, disease metastasis and disease aggressiveness, and are closely related to the expression of BCSG1, Cox-2 and mutant p53 protein. Therefore, they can be considered as diagnostic markers.