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本文报告用硝苯吡酯(nimodipine)预处理对鼠实验性颅内出血的效用观察。将成鼠48只,双盲随机分成两组,一组静滴硝苯吡酯1μg/kg/分,另组滴聚乙烯乙二醇乙醇混合液对照。 30分钟后从每鼠股动脉取血100μl经钻孔分别注入各自右颅内尾核,并继续滴注共4小时。其间每30分钟测定一次血气、局部脑血流量、颅内压、血脑屏障渗透性,最后杀死动
This article reports the effect of nimodipine pretreatment on experimental intracranial hemorrhage in mice. Will be 48 rats, double-blind randomized into two groups, a group of intravenous nifedipine 1μg / kg / min, the other group drops of polyethylene glycol ethanol mixture control. Thirty minutes later, 100 μl of blood from each rat femoral artery was injected into the respective right intracranial caudate nucleus by drilling, and the infusion was continued for a total of 4 hours. During which time every 30 minutes measured blood gas, local cerebral blood flow, intracranial pressure, blood-brain barrier permeability, and finally kill the move