患儿男,1979年8月初诊,18个月,出生后2个月于颜面部发生数个米粒大、淡黄色或黄褐色结节,无明显症状,以后数目渐增多,向前胸蔓延,继而躯干四肢颈部被累及。患儿为第二胎、母乳喂养,父母健为非近亲婚配。体检:头无畸形,发黄稀疏,肝剑突下3.5cm,肋下2.5cm,质较硬,脾未触及。躯干四肢 Children with male, first diagnosed in August 1979, 18 months, 2 months after birth in the facial part of a few large grains, light yellow or brown nodules, no obvious symptoms, after the number increased gradually spread to the chest, Then trunk neck and neck were involved. Children with a second child, breastfeeding, and parental health are non-relatives. Physical examination: head deformity, yellow sparse, liver xiphoid 3.5cm, ribs 2.5cm, the quality of hard, spleen not touched. Trunk limbs