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目的:探讨人类红细胞Lewis表型的不同是否与胃癌的发生有关。方法:应用微柱凝胶技术对63例胃癌患者及120名健康供血者的血液标本进行Lewis表型检测,比较分析两组人群红细胞Lewis表型的表达频率。结果:胃癌患者红细胞kwis(a-b+)表型频率明显高于健康对照组(79.4%VS 61.7%,P<0.05)。而其Lewis(a+b-)表型频率明显低于健康对照组(9.5%VS 22.5%,P<0.05)。结论:Lewis(a-b+)表型可能是胃癌易发的一个危险因素。
Objective: To investigate whether different Lewis phenotypes of human erythrocytes are related to the occurrence of gastric cancer. Methods: Microarray gel technique was used to detect Lewis phenotypes in 63 gastric cancer patients and 120 healthy blood donors. The frequency of Lewis phenotypes was compared between the two groups. Results: The phenotype frequency of kwis (a-b +) in patients with gastric cancer was significantly higher than that in healthy controls (79.4% vs 61.7%, P <0.05). The Lewis (a + b-) phenotype was significantly lower than that of healthy controls (9.5% vs 22.5%, P <0.05). Conclusion: Lewis (a-b +) phenotype may be a risk factor for gastric cancer.