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在29只家兔的颈动脉体-窦神经标本，记录了55个窦神经中化学感受性传入单位的电活动。结果如下：（1）灌流液pH降低时，所有单位的放电均增加，频率由0．86±0．21增至1．75±040imp／s（P＜0.001）。（2）在灌洗液中加入尼古丁（1，3，6，10和15μg/ml）后，10个单位的自发放电频率，由0．60±0.21分别增加到0．96±0．21，1．19±0.30，1．24±0．29，1．48±0．41和1．82±0．39imp／s，呈明显的剂量依赖性肝（r=0．94，P＜O．001）。简箭毒可阻断尼古丁的作用，但对自发放电无显著影响。（3）当以酸性Locke氏溶液灌流标本时，19个单位的放电频率由0.95±0．34增至1.84±0．55imp／s；在酸性灌流液中加入尼古丁后，放电频率由0.96±0．25增至1．53±0．24imp／s；与单纯酸刺激时相比，放电频率增加幅度减小（P＜0．05）。（4）17个自发放电频率为1.08±0．33imp／s的单位，换以酸性Locke氏液灌流后，放电频率增加到1．64±0．43imp／s；加筒箭毒后，由对照的1.01±0.34增至1．70±0．43imp／s；灌流液pH降低时筒箭毒对化学感受性单位放电频率的变化无显著影响。上述结果提示：（1）ACh在颈动脉体化学感受性功能方面可能仅起调质的作用。（2）pH降低时颈动脉体化学感受性功能活动增强与N-型胆碱能受体
Carotid body-sinus nerve specimens of 29 rabbits recorded the electrical activity of chemosensitive afferent units in 55 sinus nerves. The results were as follows: (1) When the pH of the perfusate decreased, the discharges of all the units increased, and the frequency increased from 0.86 ± 0.21 to 1.75 ± 040imp / s (P <0.001). (2) After adding nicotine (1, 3, 6, 10 and 15μg / ml) to the perfusate, the spontaneous firing frequency of 10 units increased from 0.60 ± 0.21 to 0.96 ± 0.21, 1.19 ± 0.30,1.24 ± 0.29,1.48 ± 0.41and1.82 ± 0.39imp / s, which showed significant dose-dependent liver (r = 0.94, P < 001). Jane virus can block the role of nicotine, but no significant effect on spontaneous discharge. (3) The discharge frequency of 19 units increased from 0.95 ± 0.34 to 1.84 ± 0.55imp / s when perfusion with acidic Locke’s solution. After adding nicotine in acidic perfusate, the discharge frequency increased from 0.96 ± 0 .25 to 1.53 ± 0.24imp / s. The increase of discharge frequency was lower than that of acid stimulation (P <0.05). (4) 17 spontaneous discharge frequency of 1.08 ± 0.33imp / s unit, replaced by acidic Locke’s liquid perfusion, the discharge frequency increased to 1.64 ± 0.43imp / s; Of 1.01 ± 0.34 increased to 1.70 ± 0.43imp / s; when the pH of perfusate was decreased, there was no significant change in the discharge frequency of chemosensory units. The above results suggest that: (1) ACh may only play a role in modulating carotid body chemosensitivity. (2) Carotid body chemosensory functional activity increased with decreased N-type cholinergic receptors