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目的 探讨胃癌及癌前病变中转化生长因子 βⅠ型受体 (TGF βRⅠ )的表达与细胞凋亡的关系及它们在胃癌发病机制中的作用。方法 免疫组化SP法检测慢性浅表性胃炎 (30例 )、肠化生 (30例 )、不典型增生 (18例 )及胃癌 (2 5例 )中TGF βRⅠ的表达 ,TUNEL法检测其中凋亡细胞的情况。 结果 从慢性浅表性胃炎到肠化生、不典型增生及胃癌 ,TGF βRⅠ表达及凋亡指数 (AI)分级均与胃粘膜病变程度显著负相关 (分别为 r =-0 72 72 ,P <0 0 1;r =- 0 8347,P <0 0 1) ,19例胃癌 (76 % )TGF βRⅠ表达缺失 ;不同组织学类型中AI的分布和TGF βRⅠ表达的分布差异无显著性 (P =0 0 779)。结论 TGF βRⅠ表达缺失可能影响细胞凋亡 ,参与胃癌的发生。
Objective To investigate the relationship between the expression of transforming growth factor β type I receptor (TGFβRI) and apoptosis in gastric cancer and precancerous lesions, and their role in the pathogenesis of gastric cancer. Methods The expression of TGF βRI in chronic superficial gastritis (30 cases), intestinal metaplasia (30 cases), atypical hyperplasia (18 cases) and gastric cancer (25 cases) was detected by immunohistochemical SP method. The condition of dead cells. Results From chronic superficial gastritis to intestinal metaplasia, atypical hyperplasia, and gastric cancer, the expression of TGFβRI and the apoptotic index (AI) were significantly negatively correlated with the severity of gastric mucosal lesions (r =-0 72 72 ,P < 0 0 1; r =- 0 8347, P <0 0 1), 19 cases of gastric cancer (76%) lack of TGFβRI expression; distribution of AI in different histological types and distribution of TGFβRI expression were not statistically significant (P = 0 0 779). Conclusion The loss of TGF βRI expression may affect apoptosis and participate in the occurrence of gastric cancer.