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目的：探讨高血压、高血糖对２型糖尿病肾病（ＤＮ）尿蛋白排泄量（ＵＰＥ）的影响。方法：测定４７例ＤＮ伴高血压患者与４０例不伴高血压ＤＮ患者的２４小时的ＵＰＥ。每组又按血压、血糖控制理想与否分为ａ，ｂ，ｃ，ｄ４小组，并比较了各小组的ＵＰＥ变化。结果：高血压、高血糖ＤＮ组ＵＰＥ显著地高于高血糖ＤＮ组（Ｐ＜０．０１）。ａ，ｂ，ｃ，ｄ各组ＵＰＥ分别是（７７６±３２２）、（２６１４±１６４０）、（６７８±１８０）、（１３０９±４６５）ｍｇ／２４ｈ。ｂ∶ｃ，ｂ∶ａ，ｂ∶ｄ，ｄ∶ａ有显著差异（Ｐ＜０．０１或０．０５），ａ∶ｃ，ｄ∶ｃ无显著差异（Ｐ＞０．０５）。结论：高血压、高血糖共同影响着尿蛋白排泄量。严格控制高血压、高血糖可减少ＵＰＥ，早期严格控制血糖能延缓或逆转疾病进程，但在显性糖尿病肾病期，控制血压更为重要
Objective: To investigate the effect of hypertension and hyperglycemia on urinary protein excretion (DN) of type 2 diabetic nephropathy (UPE). Methods: Twenty-four hours of UPE were measured in 47 patients with DN and 40 patients with hypertension without DN. Each group was divided into a, b, c, d4 groups according to blood pressure and glycemic control ideal or not, and the changes of UPE in each group were compared. Results: The UPE in hypertensive and hyperglycemic DN groups was significantly higher than that in hyperglycemic DN group (P <0.01). The UPE in groups a, b, c and d were (776 ± 322), (2614 ± 1640), (678 ± 180) and (1309 ± 465) mg / 24h, respectively. b: c, b: a, b: d, d: a significant difference (P <0.01 or 0.05), a: c, d: c no significant difference (P> 0.05). Conclusion: Hypertension and hyperglycemia together affect urinary protein excretion. Strict control of hypertension, hyperglycemia can reduce the UPE, early strict control of blood glucose can delay or reverse the disease process, but in the dominant diabetic nephropathy, blood pressure control is more important