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目的探讨降钙素原(PCT)及中性粒细胞CD64在小儿肺炎早期诊断及监测小儿肺炎严重程度中的临床意义。方法回顾性分析医院2016年1月-2017年3月收治的151例儿科肺炎患者作为研究对象,分为细菌感染组86例,病毒感染组38例,支原体感染组27例。其中,细菌感染组分为轻症组60例和重症组26例。同时选取同期健康体检儿童50例作为对照组,研究各组患儿的PCT水平及中性粒细胞CD64指数。结果细菌感染组患儿PCT及CD64指数明显高于病毒感染组、支原体感染组和健康体检组,差异有统计学意义(P<0.05);而支原体感染组PCT水平略高于病毒感染组和健康体检组,差异有统计学意义(P<0.05)。重症组肺炎患儿WBC计数、PCT、CD64、ESR较轻症组明显增高,差异有统计学意义(P<0.05)。结论 PCT及中性粒细胞CD64可用于区分患儿肺炎类别,有助于早期诊断,在评估肺炎严重程度中有重要意义。
Objective To investigate the clinical significance of procalcitonin (PCT) and neutrophil CD64 in early diagnosis of pneumonia in children and monitoring the severity of pneumonia in children. Methods A total of 151 pediatric pneumonia patients admitted from January 2016 to March 2017 in our hospital were retrospectively analyzed. There were 86 bacterial infections, 38 viral infections and 27 mycoplasma infections. Among them, the bacterial infection components were 60 cases in mild group and 26 cases in severe group. At the same time, 50 healthy children in the same period were selected as control group to study PCT level and neutrophil CD64 index in each group. Results The PCT and CD64 index of children with bacterial infection were significantly higher than those of virus infection, mycoplasma infection and healthy control group (P <0.05), while the level of PCT in patients with mycoplasma infection was slightly higher than that of virus infection and healthy The physical examination group, the difference was statistically significant (P <0.05). WBC count, PCT, CD64 and ESR in severe pneumonia group were significantly higher than those in mild group (P <0.05). Conclusion PCT and neutrophil CD64 can be used to differentiate pneumonia in children and be helpful for early diagnosis. It is of great significance in assessing the severity of pneumonia.