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目的探讨经鼻点滴枸橼酸芬太尼注射液用于控制爆发性癌痛(BTCP)的有效性。方法 18例晚期癌症且合并BTCP住院患者,均口服吗啡缓释片控制基础性癌痛,口服吗啡即释剂控制BTCP。随机分为两组(n=9):观察组在BTCP时改用枸橼酸芬太尼注射液1ml(50μg)滴鼻。对照组:继续用吗啡即释剂控制BTCP。结果观察组与对照组镇痛起效时间分别为(18.34±6.33)和(25.11±4.26)min,观察组显著短于对照(P<0.05)。观察组BTCP最大强度评分显著低于对照组(P<0.05),而患者满意度评分显著高于对照组(P<0.01)。结论枸橼酸芬太尼注射液滴鼻用于控制BTCP,给药方便,起效迅速,患者满意度高,有一定的临床应用价值。
Objective To investigate the effectiveness of nasal drip of fentanyl citrate injection in the control of BTCP. Methods 18 patients with advanced cancer and BTCP hospitalized patients were oral morphine sustained release tablets to control the basic cancer pain, oral morphine immediate release agent control BTCP. The patients were randomly divided into two groups (n = 9): the observation group was given intranasal infusion of 1ml (50μg) fentanyl citrate injection at BTCP. Control group: Continue to control BTCP with morphine immediate release agent. Results The onset time of analgesia in observation group and control group were (18.34 ± 6.33) and (25.11 ± 4.26) min, respectively. The observation group was significantly shorter than the control group (P <0.05). The BTCP score of the observation group was significantly lower than that of the control group (P <0.05), but the satisfaction score of the patients was significantly higher than that of the control group (P <0.01). Conclusion Intravenous infusion of fentanyl citrate injection for the control of BTCP, convenient administration, rapid onset, patients with high satisfaction, there is a certain clinical value.