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目的观察磷霉素钠注射液联合自拟肺心Ⅰ号方治疗慢性肺源性心脏病(CPHD)急性加重期的疗效。方法全部122例患者随机分为2组,治疗组82例,对照组40例,在常规应用吸氧、止咳、解痉平喘、强心、利尿、纠正电解质和酸碱失衡基础上,对照组给予头孢哌酮钠舒巴坦钠注射液及血塞通注射液静脉滴注,治疗组给予磷霉素钠注射液静脉滴注,并口服肺心Ⅰ号方。于治疗后检查动脉血气、血浆D—二聚体、血红蛋白和血液流变学等。结果治疗组总有效率93.90%,对照组总有效率62.50%,两组相比,差异有统计学意义(P﹤0.01),治疗组治疗后各项实验室指标改善均较对照组明显(P﹤0.05或P﹤0.01)。结论磷霉素钠联合中药治疗CPHD急性加重期疗效肯定,并发症少,复发率及死亡率低,且副作用小。
Objective To observe the efficacy of fosfomycin sodium injection combined with self-made pulmonary heart Ⅰ prescription for the treatment of acute exacerbation of chronic cor pulmonale (CPHD). Methods All 122 patients were randomly divided into two groups: the treatment group (n = 82) and the control group (n = 40). On the basis of routine application of oxygen, cough, antispasmodic and asthma, cardiac, diuresis, electrolyte correction and acid-base imbalance, the control group was given cefoperazone sodium Sulbactam sodium injection and Xuesaitong injection intravenously, the treatment group was given fosfomycin sodium injection intravenous infusion, and oral pulmonary heart Ⅰ. After treatment, check arterial blood gas, plasma D-dimer, hemoglobin and hemorheology. Results The total effective rate was 93.90% in the treatment group and 62.50% in the control group. The difference between the two groups was statistically significant (P <0.01). The improvement of each laboratory index in the treatment group was significantly (P <0.05 or P <0.01). Conclusion Fosfomycin sodium combined with traditional Chinese medicine in the treatment of acute exacerbation of CPHD positive effect, fewer complications, recurrence and mortality is low, and the side effects.