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该文报告两侧新生儿,在其眼和脑脊液中分离出同一脑膜炎双球菌株,提示眼可能是某些围产期新生儿脑膜炎双球菌感染性疾病的侵入门户,治疗新生儿化脓性结膜炎有重要意义。病例例1,足月产男婴,生后情况良好,体重3 500g。第二天左眼发炎,应用新霉素滴眼液前做拭子细菌培养。生后60小时出现惊厥(持续30秒)和脑膜炎体征。腰穿脑脊液白细胞3040×10~6/L,有大量革兰氏阴性(G~-)双球菌。头孢氨噻肟和氨苄青霉素治疗两周痊愈,无并发症。眼拭子、血液和脑脊液中,母亲高位阴道拭子及父亲咽拭子均培养出C组2a型脑膜炎双球菌。母亲用甲硝哒唑和头孢氨呋肟,在确定细菌后父母亲均用利福平治疗。
The article reports newborns on both sides and isolates the same meningococcal strain in both eyes and cerebrospinal fluid, suggesting that the eye may be the entry point for some perinatal neonatal meningococcal infectious disease to treat neonatal purulent Conjunctivitis is of great importance. Case 1, full-term baby boy, after birth in good condition, weighing 3 500g. Left eye inflammation the next day, apply neomycin eye drops before swab bacterial culture. Convulsions (lasting 30 seconds) and signs of meningitis 60 hours after birth. Waist wear cerebrospinal fluid leukocytes 3040 × 10 ~ 6 / L, a large number of Gram-negative (G ~ -) meningitis. Cefotaxime and ampicillin cured two weeks, no complications. Eye group swab, blood and cerebrospinal fluid, the mother of high vaginal swabs and throat swabs were cultured Group C Group 2a meningitis. Mothers with metronidazole and cefuroxime, parents in the determination of bacteria were treated with rifampicin.