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本文对急性出血坏死性胰腺炎（ＡＨＮＰ）时的内毒素血症（ＥＴＭ）进行实验研究和临床观察。研究中应用Ｗｉｓｔａｒ大鼠５个系列２ｌ４只，观察了２４例急性胰腺炎病人，并应用茵陈蒿承气汤（合方）对急性胰腺炎时的ＥＴＭ进行防治。结果发现，实验性ＡＨＮＰ血浆内在素（ＥＴ）含量随致病原浓度加大而升高，相同浓度致病后ＥＴ含量到４８小时达到高峰，ＥＴ含量高则病情重死亡率高；合方可使ＥＴ含量下降，防治组和治疗组的死亡卒分别为１８．２％和２８．１％，明显低于对照组的５３．３％；临床观察到同样的疗效。合方具有维持肠血屏障和胆血屏障的作用，能够提高机体免疫力、拮抗和清除ＥＴ等，从而发挥其法邪扶正之功效，深入阐明了中西医结合是防治急性胰腺炎的有效手段。
In this paper, experimental and clinical observation of endotoxemia (ETM) in acute hemorrhagic necrotizing pancreatitis (AHNP) was conducted. Wistar rats were used in the study of 5 series 2l4, 24 patients were observed in patients with acute pancreatitis, and the use of Yin Chen Hao Chengqi Decoction (combination) in the prevention and treatment of acute pancreatitis ETM. The results showed that the content of endothelin (ET) in plasma of experimental AHNP increased with the increase of pathogenicity, the peak of ET reached the peak at 48 hours after the same concentration of pathogenicity, and the high mortality of ET was high; So that the ET content decreased, the prevention and treatment of death and death were 18.2% and 28.1%, significantly lower than the control group of 53.3%; clinically observed the same effect. The combination has the function of keeping the intestinal blood barrier and the bile-blood barrier, improving the immunity of the body, antagonizing and eliminating the ET and so on, thereby exerting the efficacy of its remedial measures, and clarifying the combination of traditional Chinese and western medicine is an effective means of preventing and treating acute pancreatitis.