【摘 要】
：
Objective:To investigate the effects of interleukin-18(IL-18)on implanted Lewis lung cancer in suppressing angiogenesis and lymphangiogenesis.Methods:One week a
【机 构】
：
Department of Oncology,Department of Respiratory
【基金项目】
：
the Natural Science Foundation of Fujian Province;Scholastic Development Foundation of Fujian Medical University
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Objective:To investigate the effects of interleukin-18(IL-18)on implanted Lewis lung cancer in suppressing angiogenesis and lymphangiogenesis.Methods:One week after hypodermic inoculation of Lewis cells,sixteen tumor-bearing syngeneic mice were randomly divided into two groups.The mice in the treatment group(group A)were intraperitoneally injected with the IL-18 and in the control group(group B)were intraperitoneally injected with normal saline for 7 days.The mice were killed on day 19.The morphology of the tumors was studied,the growth curve was described and the tumor inhibition rate was calculated.The numbers of metastasized pulmonary colonies were calculated using hematoxylin-eosin(HE)staining.The vascular endothelial growth factor A(VEGF-A),vascular endothelial growth factor C(VEGF-C),microvessel,density(MVD)and lymphatic microvessel density(LMVD)in tumor mass were measured by immunohistochemistry staining(IHCS).Results:In the group A,the tumor volume,tumor weigh,lung metastatic nodules,expression of VEGF-A and VEGF-C,MVD were all decreased significantly(P
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