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目的 :对肠溶丙烯酸树酯进行致突变作用研究及其安全性评价。方法 :Ames试验、CHL细胞染色体畸变试验、小鼠骨髓嗜多染红细胞微核试验。结果 :肠溶丙烯酸树酯Ames试验、CHL细胞染色体畸变试验、小鼠骨髓微核试验均为阴性。结论 :在体内、外条件下 ,肠溶丙烯酸树酯无致突变作用。
Objective: To study the mutagenicity of enteric acrylic resin and its safety evaluation. Methods: Ames test, CHL cell chromosome aberration test, mouse bone marrow polychromatic erythrocyte micronucleus test. Results: Enteric-coated acrylic resin Ames test, CHL cell chromosome aberration test, and mouse bone marrow micronucleus test were negative. CONCLUSIONS: Enteric-coated acrylics have no mutagenic effects in vivo and in vitro.