肝癌是世界上最常见的肿瘤之一,在中国的发病率及死亡率均高,严重危害着人们的健康,其发生、发展是多因素、多步骤的复杂过程[1]。miRNA是一类短序列RNA分子,已有研究证实,单核苷酸多态性(SNP)可以影响miRNA对靶基因的调控过程,参与许多疾病如神经系统疾病、感染性疾病、心血管 Liver cancer is one of the most common tumors in the world. Its incidence and mortality in China are both high and seriously endangering people’s health. The occurrence and development of liver cancer are multifactorial and multi-step complex processes [1]. MiRNAs are a kind of short sequence RNA molecules. It has been reported that single nucleotide polymorphisms (SNPs) can affect the regulation of miRNAs on target genes and are involved in many diseases such as nervous system diseases, infectious diseases, cardiovascular diseases