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目的:通过对青少年甲状腺癌患者的临床特征、治疗方法以及患者预后的分析和总结,为将来青少年甲状腺癌的治疗提供合理的治疗思路和方法。创新点:回顾20年的青少年甲状腺癌患者的临床特征和治疗方式,分析治疗模式和观念的衍变,结合指南推荐,总结本中心对青少年甲状腺癌的治疗体会和经验,为青少年甲状腺癌患者提供更合理的治疗方式。方法:回顾性分析本中心1990年1月至2010年12月期间收治的青少年甲状腺癌患者,并对其预后进行随访。根据年龄以12岁为界分成≤12岁和>12岁两组,分析两组患者的发病率、淋巴结转移、远处转移、腺外侵犯、治疗方法和预后情况。结论:所有青少年甲状腺癌患者以分化型癌为主,小于12岁患者的淋巴结转移率要明显高于大于12岁组,同时在高龄组的患者中,女性的发病率要高于男性。在腺外侵犯、远处转移、死亡率以及复发性疾病等其他方面,两组无显著性差异。青少年甲状腺癌患者的总体预后较好,选择手术为主的综合性治疗方式将会得到较为满意的效果。
Objective: To provide a reasonable treatment idea and method for the treatment of thyroid cancer in the future through analyzing and summarizing the clinical features, treatment and prognosis of thyroid cancer in adolescents. Innovative point: Review of 20 years of young patients with thyroid cancer clinical features and treatment, analysis of treatment patterns and concepts of evolution, combined with the guidelines recommended to summarize the Center for young thyroid cancer treatment experience and experience for young patients with thyroid cancer provide more Reasonable treatment. Methods: A retrospective analysis of our center from January 1990 to December 2010 admitted to adolescent thyroid cancer patients, and its prognosis were followed up. According to the age of 12 years old, the patients were divided into two groups of ≤12 years old and> 12 years old. The incidence, lymph node metastasis, distant metastasis, extrahepatic invasion, treatment and prognosis of the two groups were analyzed. Conclusion: All adolescent patients with thyroid cancer are differentiated carcinomas. The rate of lymph node metastasis in patients younger than 12 years old is significantly higher than that in patients older than 12 years old. In the elderly group, the incidence of women is higher than that of men. In other aspects of extra-gland invasion, distant metastasis, mortality and recurrent disease, there was no significant difference between the two groups. Adolescent thyroid cancer patients with better overall prognosis, the choice of surgery-based comprehensive treatment will be more satisfied with the results.