Paulownia fortunei has been successfully used in the phytoremediation of many Pb/Zn mine tailings.However,seed germination and young seedlings of P fortunei rarely occurred in these mine tailings.The physiological responses and detoxific mechanisms of P.fortunei young seedling to Pb,Zn,Cu and Cd stress were investigated.The germinated rate,shoot length,chlorophyll and carotenoid contents in leaves of young seedlings had a great reduction under Zn and Cu treatments,but had little decrease under Pb and Cd and Cu indicating great oxidative stress for young seedlings,but they had no significant change to added Pb and Cd.Young seedlings had effective detoxific mechanism to Pb and Cd,as antioxidant enzymes activities,phytochelatins (PCs-SH) and proline contents increased with increasing rates of added Pb and Cd.However,young seedlings had un-effective detoxific mechanisms to Zn and Cu stress.Results revealed the heavy metals (such as Cu) that present at low concentrations in mine tailings may be major constraint for the survival of young seedlings.