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目的:研究辛伐他汀、琥乙红霉素联合使用对于糖尿病患者肾脏的保护作用.方法选取160例我院2010年6月~2013年6月期间收治的糖尿病患者,将所有患者随机分为两组各60例,对照组80例,在降血压、降血糖的基础上给予辛伐他汀进行治疗;治疗组80例,在对照组降压降糖治疗的基础上,同时给予辛伐他汀联合琥乙红霉素进行治疗.治疗20周后,观察两组患者治疗前后的C-反应蛋白(CRP)、白细胞介素-6(IL-6)、尿白蛋白(Pro)、肾小球滤过率(GFR)等肾功能指标的变化.结果两组患者治疗后发现,与治疗前相比,治疗后差异显著,P<0.05差异有统计学意义;对照组与观察组对比,观察组对肾脏保护效果更好,(P<0.05)差异有统计学意义.结论辛伐他汀联合琥乙红霉素对于糖尿病肾脏具有很好的保护效果,值得临床应用及推广. “,”Objective To study the protective effect of the combined use of thekidney of diabetic patients with simvastatin,erythromycin ethylsuccinate.Methods 160 cases of diabetic patients in our hospital during 2010.6-2013.6,divided all patients into two groups of 60 cases,80 cases in the control group,on the basis of blood pressure lowering,hypoglycemic with simvastatintreatment;80 cases in the treatment group,the control group in the basis ofhypotension hypoglycemic treatment,while giving the simvastatin erythromycin Ethylsuccinate treatment. After 20 weeks of treatment,observation of C-reactive protein in two groups of patients before and after treatment (CRP),interleukin -6 (IL-6), urinary albumin (Pro),glomerular filtration rate (GFR)changes in renal function indexes.Results The two groups of patients after the treatment,compared with before treatment,after treatment significantly,P〈0.05;the control group and the observation group contrast group,observe thebetter effect on renal protection,P〈0.05.Conclusion Simvastatin combined with erythromycin Ethylsuccinate has good protective effect on diabetic kidney,worthy of clinical application and promotion.