美国北卡罗来纳州达勒姆消息:Duke大学神经病学副教授Ara Tourian报告,抗高血压和抗抑郁症的新的联合用药有助于缓解病人因严重周围神经损伤所致的长期顽固性疼痛。 11例对其它治疗无效的病人联合用哌唑嗪(Pra-zosin)和多虑平(Doxepin)治疗,证明对周围神经损伤所致的长期疼痛有效。这两种药物均有独自的止痛效果。此方法可避免应用麻醉剂。哌唑嗪是α_1受体阻滞剂。动物研究显示有阻滞肾上腺素能神经递质的作用,对损伤的周围神经组织非常敏感。多虑平可通过提高去甲肾上腺素能在中枢神经系统的水平减轻疼痛,或可能在脊髓的后角和接受 Darham, North Carolina, USA: Ara Tourian, an associate professor of neurology at Duke University, reports that a new combination of antihypertensive and antidepressant drugs helps to relieve long-term intractable pain in patients with severe peripheral nerve injury. Eleven patients who did not respond to other therapies were treated with Pra-zosin and Doxepin to prove that they were effective in long-term pain caused by peripheral nerve injury. Both drugs have their own analgesic effect. This method avoids the use of anesthetics. Prazosin is an alpha 1 receptor blocker. Animal studies have shown that there is blockade of adrenergic neurotransmitter effects, is very sensitive to damaged peripheral nerve tissue. Doxepin may relieve pain at the level of the central nervous system by increasing noradrenaline, or may be at the cusp and accepting of the spinal cord