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Nemo样激酶(Nemo-like kinase,NLK)是一种进化上保守的促分裂原活化蛋白激酶类似的激酶,属于丝氨酸/苏氨酸蛋白激酶超家族成员。NLK可以通过参与Wnt、Notch、FoxO等多条通路调节细胞增殖、分化、胚胎发育早期形态学变化和脊椎动物神经系统发育等生物过程。NLK还是肿瘤调控中的一个关键分子,在不同的肿瘤中起到不同的作用,在前列腺癌、非小细胞肺癌、卵巢癌、乳腺癌中NLK可以抑制肿瘤的发生与发展,在肝癌、口腔鳞癌、胆管癌等肿瘤中却有着相反的作用。
Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein kinase-like kinase that belongs to the serine / threonine protein kinase superfamily member. NLK can regulate biological processes such as cell proliferation, differentiation, early embryonic morphological changes and vertebrate nervous system development by participating in multiple pathways such as Wnt, Notch and FoxO. NLK is also a key molecule in tumor regulation and plays a different role in different tumors. NLK can inhibit the occurrence and development of tumors in prostate cancer, non-small cell lung cancer, ovarian cancer and breast cancer. In liver cancer, Cancer, cholangiocarcinoma and other tumors have the opposite effect.