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[目的]研究KAI1/CD82与E-cadherin在子宫内膜癌组织中的表达及其与临床病理参数的关系。[方法]采用免疫组织化学EnVision二步法检测76例子宫内膜癌,15例非典型增生子宫内膜和20例正常增生期子宫内膜组织中KAI1/CD82、E-cadherin的表达。[结果]KAI1/CD82在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的阳性表达率分别为95%、93.3%和60.5%;E-cadherin在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的异常表达率分别为0、6.67%和55.26%。KAI1/CD82在子宫内膜癌的表达与组织学分级、肌层浸润程度呈负相关(P=0.000,P=0.01)。E-cadherin在子宫内膜癌的表达与组织学分级及组织学类型有关。KAI1/CD82与E-cadherin在子宫内膜癌中的表达呈显著性相关(P<0.01)。[结论]KAI1/CD82表达下调和E-cadherin异常表达增高与子宫内膜癌的进展有关。
[Objective] To investigate the expression of KAI1 / CD82 and E-cadherin in endometrial carcinoma and its relationship with clinicopathological parameters. [Method] The expression of KAI1 / CD82 and E-cadherin in 76 cases of endometrial carcinoma, 15 cases of atypical hyperplasia endometrium and 20 cases of normal proliferative endometrium were detected by immunohistochemistry EnVision two-step method. [Results] The positive expression rates of KAI1 / CD82 in normal proliferative endometrium, atypical hyperplastic endometrium and endometrial carcinoma were 95%, 93.3% and 60.5%, respectively. The expression of E-cadherin in normal proliferative endometrium, The abnormal expression rates of atypical hyperplastic endometrium and endometrial carcinoma were 0, 6.67% and 55.26% respectively. The expression of KAI1 / CD82 in endometrial carcinoma was negatively correlated with histological grade and myometrial invasion (P = 0.000, P = 0.01). E-cadherin expression in endometrial cancer and histological grade and histological type. The expression of KAI1 / CD82 and E-cadherin in endometrial carcinoma were significantly correlated (P <0.01). [Conclusion] The down-regulation of KAI1 / CD82 expression and the abnormal expression of E-cadherin are associated with the progression of endometrial carcinoma.