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目的 探讨大剂量顺铂与阿霉素、环磷酰胺联合治疗晚期乳腺癌的疗效与毒副反应。方法 治疗病理确诊的晚期乳腺癌 33例。用药 :HD -DDP 40 0mg/m2 ,静滴 ,d1;ADM(或THP) 40mg/m2 ,静冲 ,d3;CTX 5 0 0mg/m2 ,静冲 ,d3、d10 。每 4周重复。结果 CR 8例 ,占 2 4 2 % (8/2 3) ;PR 18例 ,占 5 4 5 % (18/33) ;CR +PR 87 7% (2 6 /33)。不良反应主要为上消化道反应、骨髓抑制及脱发。结论 大剂量顺铂为主的PAC方案治疗晚期乳腺癌疗效满意 ,不良反应低 ,病人能够耐受
Objective To investigate the efficacy and side effects of high-dose cisplatin combined with doxorubicin and cyclophosphamide in the treatment of advanced breast cancer. Methods 33 cases of pathologically diagnosed advanced breast cancer. Medication: HD -DDP40 0mg / m2, intravenous infusion, d1; ADM (or THP) 40mg / m2, static Chong, d3; CTX50mg / m2, static Chong, d3, d10. Repeat every 4 weeks. Results CR 8 cases, accounting for 24.2% (8/2 3); PR 18 cases, accounting for 54.5% (18/33); CR + PR 87 7% (26/33). Adverse reactions are mainly upper gastrointestinal reactions, bone marrow suppression and hair loss. Conclusion High-dose cisplatin-based PAC regimen is effective in treating advanced breast cancer with low adverse reactions and patients can tolerate