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目的 观察癌基因 C-erb B-2在宫颈癌组织中表达对放疗预后的影响。方法 宫颈癌组织标本取自我院 1980— 1981年放疗后满 10 a病例 99例 ,1996— 1998年放疗前确诊病例 2 9例。采用 LSAB免疫组织化学染色 ,细胞膜呈棕黄色反应为 C-erb B-2阳性。 60钴外照射总剂量 45 0 0～ 5 0 0 0 c Gy/B点 ,腔内治疗1 3 7铯 70 0 0～80 0 0 c Gy/A点或 1 92铱 42～ 5 0 Gy/A点。结果 在 5 1例放疗后满 10 a生存病例中 ,C-erb B-2阳性为 47% ,而死亡 48例中阳性表达 72 % ,P<0 .0 5。 2 9例放疗结束 :11例 C-erb B-2阳性 ,完全缓解 (CR)、部分缓解 (PR)各为72 .7%和 2 7.3 % ,18例阴性表达 ,CR、PR各为 72 .8%和 2 7.2 %。结论 放疗后满 10 a生存病例 C-erb B-2阳性表达明显低于死亡病例 (P<0 .0 1) ,差异有显著意义。C-erb B-2阳性或阴性尚看不出与宫颈癌放疗近期疗效的关系
Objective To observe the effect of oncogene C-erb B-2 expression on the prognosis of cervical cancer. Methods Cervical cancer tissue samples were taken from 99 cases in 10 years after radiotherapy in our hospital from 1980 to 1981 and 29 cases diagnosed before 1996-1998. LSAB immunohistochemical staining, the cell membrane was brown-yellow C-erb B-2 positive. The total dose of cobalt 60 exposure was 45 0 0 ~ 50 000 c Gy / B, and the intracavitary treatment was 1 3 7 cesium 70 0 0 ~ 80 0 0 c Gy / A or 1 92 iridium 42 ~ 500 Gy / A point. Results Of the 51 patients who survived for 10 years after radiotherapy, the positive rate of C-erb B-2 was 47%, while the positive rate of 72 patients was 48%, P <0.05. The end of radiotherapy was completed in 29 cases. The positive rate of complete remission (CR) and partial remission (PR) were 72.7% and 7.3% in 11 cases of C-erb B-2, respectively. 8% and 7.2%. Conclusions The positive expression of C-erb B-2 in the 10-year-survival cases after radiotherapy is significantly lower than that of the death cases (P <0.01), and the difference is significant. C-erb B-2 positive or negative still do not see the relationship between cervical cancer and the recent efficacy of radiotherapy