Role of the Pentanucleotide (tttta)n Polymorphisms of CYP11α Gene in the Pathogenesis of Hyperandrog

来源 :华中科技大学学报(医学英德文版) | 被引量 : 0次 | 上传用户:wayl1s1s
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
To determine the (tttta)n repeat polymorphisms at the promoter region of CYP11α gene,and study its linkage to hyperandrogenism of polycystic ovary syndrome (PCOS) in Chinese women, a case-control study was conducted in the Reproductive Medical Center of the Second Affiliated Hospital of Zhengzhou University (Zhengzhou, China). 96 PCOS patients and 78 healthy control women were included. CYP11α (tttta)n repeat-polymorphism genotyping analysis was performed by using polymerase chain reaction (PCR). Serum pituitary hormone and total testosterone levels were measured by ELISA. 4 different CYP11α (tttta)n allelles were identified, corresponding to 4-, 6-, 8-, and 9-repeat-unit alleles. The frequency and distribution of these alleles are 0. 16,0.33, 0.38, and 0. 13 respectively in PCOS patients, as compared with 0. 20, 0.34, 0. 35, and 0.11 respectively in healthy controls. There were no significant differences between these two groups. Moreover, no correlation between the polymorphism of CYP11α gene and serum testosterone level of patients with PCOS and controls was observed. It is concluded that microsatellite polymorphism (tttta)n of gene CYP11α exists in Chinese women and the polymorphism of CYP11α gene does not play an important role in the pathogenesis of Chinese patients with PCOS, especially in patients with hyperandrogenism.
其他文献
柏林起重机服务提供商Mobi-Hub近期购买了Terex(R)CC 2800-1型履带式起重机,该起重机从德国茨韦布吕肯生产地直接运送到科布伦茨附近的Mobi-Hub工地,用于安装1台ENERCON风机.
期刊
@@
近日,JLG(捷尔杰)1850SJ型自行式直臂高空作业平台在日内瓦参与一个旧址改建项目,凭借“兼具高度和效率”的优势,起到了至关重要的作用。此次项目改建是将一家普通的面粉厂及
期刊
@@
Objective To determine the susceptibilities of M. tuberculosis H37Ra and M. chelonei subsp. absecessus to several frequently-used disinfectants and to evaluate
位于黄海之滨的连云港,不仅以花果山水帘洞著称于世,其终年不冻的天然气候更使她成为中国沿海十大海港、全球百强集装箱运输港口之一.在这里,一家集团化企业分属的物流园内,
期刊
@@
配备博世力土乐EDIS(按需提供能量的工作系统)的轮式装载机,比单纯使用双齿轮系统的轮式装载机,油耗降低可达10%,切实提高用户经济效益.中国终端设备制造商的首轮测试显示,短
期刊
@@
To analyze the polymorphism of TAP gene and the shared rates of alleles between mothers and their infants in Chinese patients with pre-eclampsia, TAP1 and TAP2
受森泰英格(成都)数控刀具有限公司委托,由中国刀协组织邀请成都工具研究所有限公司董事长罗勇(研高)、成都工具研究所资深刀具专家赵炳桢(研高)、中国刀协秘书长黄宁秋(研高
期刊
@@
To investigate the effects of WIN 55,212-2 on IK in cultured rat trigeminal ganglion (TG) neurons, whole-cell patch clamp techniques were used to record the IK
Objective: To observe the effect of Tribuli saponins (TS) on left ventricularremodeling after acute myocardial infarction(AMI) in rats with hyperlipemia. Method
Objective To describe the specific features of the contact history of probable cases of severe acute respiratory syndrome (SARS) in Beijing. Methods Data of SAR