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乙双吗啉(AT_(1727))化学全称1,2-双[N~4-吗啉甲撑-3,5-二氧哌嗪]乙烷,是我国上海药物所合成的一种新药。据报导,它有明显的抗肿瘤作用,化疗指数较高。61.80%患辐射抗性肿瘤的病人经~(60)Co γ线和AT_(1727)合并使用治疗,获明显效果。本文采用小鼠腹水瘤S-180 V细胞,用碱洗脱膜过滤法观察了乙双吗啉对DNA损伤与修复的影响。乙双吗啉先用HCl溶解,生理盐水稀释,照射前加到细胞悬液中,37℃保温1h,使
Bismuth morpholine (AT_ (1727)) The chemical name of 1,2-bis [N 4-morpholino-3,5- dioxopiperazine] ethane, is a new drug synthesized by Shanghai’s Shanghai drugs. It has been reported that it has obvious anti-tumor effect and high chemotherapy index. 61.80% of patients with radiation-resistant tumors by ~ (60) Co γ ray and AT_ (1727) combined treatment with significant effect. In this paper, mouse ascites tumor S-180 V cells, with alkali elution membrane filtration method observed B-morphine on DNA damage and repair. B-morpholine first dissolved in HCl, diluted with saline, added to the cell suspension before irradiation, 37 ℃ incubated 1h, so that