Artificially induced tetraploid Pacific oyster, Crassostrea gigas Thunberg, produces more aneuploid gametes than normal diploid one, although they showed a comparable fecundity to diploidy. The meiotic chromosome configuration of 3 tetraploid and 1 tetraploid/triploid mosaic males were analyzed through direct chromosome observation. A majority of metaphase I spermatocytes contained both bivalents and quadrivalents. The chromosome configuration of these males was characterized by preferential formation of bivalents to quadrivalents. Bivalents appeared in all spermatocytes and consisted of 86% of all chromosome aggregates. In comparison, quadrivalents occurred in 91% spermatocytes and consisted of only 12.6% of all chromosome aggregates. The mean bivalent frequency per spermatocyte varied between 14.4 and 17.2; while that of quadrivalents varied between 2.2 and 2.7. Most quadrivalents were tandemly chained(58%) or circled(39%). The total number of chromosome aggregates per spermatocyte ranged from 13 to 20 with an average of 17.6; while 18(16 bivalents and 2 quadrivalents) was the most frequent. Univalents and trivalents appeared in very low frequency. Aneuploid(hypotetraploid) spermatocytes were observed in a low frequency. The chromosome configuration of in the mosaic individual was similar to that of tetraploid individuals. The percentage of triploid spermatocytes(2%) of the mosaic individual was significantly lower(χ2 =30, P < 0.01) than that of triploid cells(46%) in its somatic tissue. Artificially induced tetraploid Pacific oyster, Crassostrea gigas Thunberg, although they showed a comparable fecundity to diploidy. The meiotic chromosome configuration of 3 tetraploid and 1 tetraploid / triploid mosaic males were analyzed through direct chromosome observation. A majority of metaphase I spermatocytes contained both bivalents and quadrivalents. The chromosome configuration of these males was characterized by preferential formation of bivalents to quadrivalents. In common, quadrivalents occurred in 91% The mean bivalent frequency per spermatocyte varied between 14.4 and 17.2; while that of quadrivalents varied between 2.2 and 2.7. Most quadrivalents were tandemly chained (58%) or circled (39%). The total number of chromosome aggregates per spermatocyte r The chromosome configuration of an 18-month-old female with an average of 17.6; while 18 (16 bivalents and 2 quadrivalents) was the most frequent. The percentage of triploid spermatocytes (2%) of the mosaic individual was significantly lower (χ2 = 30, P <0.01) than that of triploid cells (46%) in its somatic tissue .