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小蘗碱对许多病原菌有抗菌作用,临床上广泛用于治疗细菌性痢疾,效果良好。关于小蘗碱的定量方法文献记载有重量法、容量法、电流滴定法、离子交換测定法、非水溶剂滴定法、极谱分析法、分光光度法等。彭煜南用硝酸比色法测定小蘗碱,操作仍较麻烦,需加热、恆温等手续。我国普遍采用苦味酸沉淀法测定小蘗碱及其制剂的含量,该法的缺点是专属性差,操作繁瑣,效率较低。远在1885年Hofmeister和Lenz曾指出,氯水加到盐酸小蘗碱水溶液中呈现红色反应,反应的灵敏度为10微克。作者用以下方法可使检出限量达1微克,限界稀度为
Berberine antibacterial effect on many pathogens, clinically widely used in the treatment of bacterial dysentery, the effect is good. Quantitative methods for the determination of berberine are described in Gravimetric, Volumetric, Current Titrimetric, Ion Exchange, Non-aqueous Titrimetric, Polarographic, and Spectrophotometric methods. Peng Yu-nan nitrate colorimetric determination of berberine, the operation is still cumbersome, to be heated, constant temperature and other procedures. In our country, the content of berberine and its preparation is generally determined by picric acid precipitation method. The disadvantages of this method are poor specificity, cumbersome operation and low efficiency. As far back as 1885 Hofmeister and Lenz have pointed out that chlorine water added to the aqueous solution of berberine hydrochloride showed a red reaction, the sensitivity of the reaction was 10 micrograms. The authors can use the following method to detect the limit of up to 1 microgram, limit the dilution of