论文部分内容阅读
目的 探讨一氧化氮 (NO)在2型糖尿病患者血管病变中的意义。方法 用生化比色法及RIA法分别检测了不同尿白蛋白排泄率 (UAER)的糖尿病患者血NO2 - +NO3 -及环鸟苷一磷酸 (cGMP)水平以及尿NO2 - +NO3 -和cGMP的排泄率。结果 2型糖尿病无或伴亚临床型糖尿病肾病者NO生成增多 ,活性下降 ;发展到临床型糖尿病肾病期 ,体内NO2- +NO3- 水平下降 ,cGMP水平继续下降。结论 NO/cGMP途径的障碍可能介导了糖尿病肾病的发生、发展 ,血或尿NO2 - +NO3 -的测定可望成为较UAER更敏感的筛选糖尿病肾病高危人群的指标
Objective To investigate the significance of nitric oxide (NO) in the pathological changes of type 2 diabetic patients. Methods The levels of NO2 - + NO3 - and cyclic guanosine monophosphate (cGMP) and urinary NO2 - + NO3 - and cGMP in diabetic patients with different urinary albumin excretion rate (UAER) were measured by biochemical colorimetry and RIA method respectively Excretion rate. Results NO production and activity decreased in patients with type 2 diabetes mellitus without subclinical diabetic nephropathy. In the stage of clinical diabetic nephropathy, NO2- + NO3- level decreased and cGMP level continued to decline. Conclusions The disorder of NO / cGMP pathway may mediate the occurrence and development of diabetic nephropathy, and the determination of NO2 - + NO3 - in blood or urine is expected to be more sensitive than UAER in the screening of high risk population of diabetic nephropathy