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The natural loess that covers the ground surface has good stability due to its low water content.However,when violent earthquakes occur,the strong dynamic stress generated in the slope may induce landslide disasters with different sizes.In this paper,a large-scale shaking table model test is used to reveal the dynamic response and instability failure process of the loess slope.The test results show that different parts of the slope have different vibration characteristics and the first natural frequency in the model increases with the increase of the slope height.The response acceleration of different parts may change due to the coupling relationship between the spectral characteristics of input wave and the natural frequencies of different parts of slope,suggesting the characteristics of regional differential dynamic response.Under the condition of different dynamic response,stress state and boundary conditions of different parts of slope,a rapid microstructural damage,cumulative residual deformation evolution,and tension-shear coupling instability failure process may appear at the top of the slope with the strong dynamic response associated with the increase of dynamic loading intensity.The Sd values presented in this paper may reflect soil damage and slope instability and failure.