2型糖尿病(T2DM)的主要病理生理改变表现为胰岛β细胞功能的进行性减退及胰岛素抵抗。英国糖尿病前瞻性研究(UKPDS)显示T2DM在确诊时β细胞功能减退约达50%,推荐早期应用胰岛素治疗能够更好地改善血糖控制并且能够保护内源性胰岛素的分泌功能[1]。我们采用甘精胰岛素联合阿卡波 The major pathophysiological changes in type 2 diabetes mellitus (T2DM) are the progressive decline of pancreatic β-cell function and insulin resistance. The UK Diabetes Prospective Study (UKPDS) has shown that beta-cell dysfunction in T2DM is estimated to be about 50% at the time of diagnosis. It is recommended that early application of insulin therapy improves glucose control better and protects endogenous insulin secretion [1]. We use glargine plus acarbose