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目的 探讨在普通光镜下如何识别新型隐球菌及脑脊液中新型隐球菌数量与预后的关系。方法 在入院及治疗１月后各腰穿取脑脊液３～４ｍｌ，充入白细胞计数池内，观察隐球菌形态并计数。分析隐球菌数量动态变化与临床疗效的关系。结果 隐球菌与细胞在高倍镜下形态明显不同。２例首次脑脊液隐球菌数＞２００×１０６／Ｌ者，均恶化。脑脊液隐球菌数小于５０×１０６／Ｌ的３例患者全部治愈。治疗１月后４例隐球菌转为阴性者１例好转，３例痊愈；２例隐球菌数大于２００ ×１０６／Ｌ者，病情无好转。结论 脑脊液隐球菌数量与临床疗效及预后有关。
Objective To investigate the relationship between the number of Cryptococcus neoformans and prognosis in Cryptococcus neoformans and cerebrospinal fluid (CSF) in common light microscopy. Methods After admission and treatment of lumbar lumbar lumbar puncture, 3 ~ 4ml cerebrospinal fluid (CSF) was inserted into the white blood cell counting pool to observe the morphology and count of cryptococcosis. Analysis of dynamic changes in the number of cryptococci and the relationship between clinical curative effect. Results Cryptococcus and cells under high magnification significantly different morphology. 2 cases of first time CSF cryptococcosis> 200 × 106 / L were deteriorated. Three patients with cryptococcal CSF less than 50 × 106 / L were cured. After 1 month, 4 cases of Cryptococcus neoformans turned negative, 1 case improved, 3 cases recovered; 2 cases of cryptococcal more than 200 × 106 / L, the disease did not improve. Conclusion The number of cryptococcal cerebrospinal fluid is related to clinical efficacy and prognosis.