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染色质的结构单位是核小体,它由DNA环绕组蛋白八聚体1.75圈组成的。macroH2A与组蛋白具有同源性,它还有活性尚不清楚的巨大C端结构域。异型组蛋白macroH2A1和macroH2A2在雌性哺乳动物与X染色体失活有关。在体外Mac-
The structural unit of chromatin is the nucleosome, which consists of 1.75 circles of DNA-wrapped histone octamer. MacroH2A has homology to histones, as well as a vast C-terminal domain whose activity is unclear. The heteromorphic proteins macroH2A1 and macroH2A2 are involved in inactivation of the X chromosome in female mammals. In vitro Mac-