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探讨骨髓增生异常综合征(myelodysplastic syndrome,MDS)的危险因素。方法 :对我院102例初诊的MDS患者和102名性别、年龄匹配的健康对照者进行1∶1配对的病例-对照研究,调查受试者的一般情况、毒物接触史、使用抗肿瘤药物史、染发史、放射线接触史和肿瘤家族史等,并应用Logistic回归对资料进行统计分析,估计人群归因危险度。结果:Logistic回归分析显示,染发剂的种类、使用频率和年限是MDS发生的危险因素,其OR值分别为2.36、2.23和2.11,调整归因危险度分别为19.80%、17.12%和15.64%,综合归因危险度为30.63%。结论:染发剂的使用与MDS的发生有关。
To explore the risk factors of myelodysplastic syndrome (MDS). Methods: A case-control study was conducted in 102 patients with newly diagnosed MDS in our hospital and 102 healthy, age-matched controls in a 1: 1 paternity case to investigate the general condition of the subjects, the history of exposure, the history of the use of antineoplastic agents , History of hair coloring, history of radiation exposure and family history of cancer, etc. Logistic regression was used to make statistical analysis on the data to estimate the attribution risk of the population. Results: The logistic regression analysis showed that the types, frequency and age of hair dye were the risk factors for MDS. The odds ratios for risk of MDS were 2.36, 2.23 and 2.11, respectively. The adjustment risk was 19.80%, 17.12% and 15.64% The composite attribution risk is 30.63%. Conclusion: The use of hair dye is related to the occurrence of MDS.