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基质金属蛋白酶(MMPs)是一组能降解细胞外基质(ECM)的蛋白水解酶类,参与组织的损伤与修复,其上调的活性可能参与肠黏膜炎症的上皮损伤。基质金属蛋白酶组织抑制因子(TIMPs)是一组具有抑制MMPs功能的活性多肽,其在MMPs活性的表达及ECM代谢的调节中起非常重要的作用。炎症性肠病(IBD)是一组病因和发病机制尚不十分明确的慢性非特异性肠道炎症性疾病,MMPs主要通过降解ECM、促进细胞凋亡、影响新生血管生成、促进细胞因子释放等多种途径参与IBD及其并发症的发生、发展。加强对MMPs/TIMPs的研究,有利于进一步深入探讨IBD的发病,对探索新的治疗方法具有重要意义。
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the extracellular matrix (ECM) and are involved in tissue damage and repair. The upregulated activity may be involved in epithelial damage of intestinal mucosal inflammation. Tissue inhibitors of matrix metalloproteinase (TIMPs) are a group of active peptides with the function of inhibiting MMPs, which plays a very important role in the expression of MMPs and the regulation of ECM metabolism. Inflammatory bowel disease (IBD) is a group of chronic non-specific intestinal inflammatory diseases whose etiology and pathogenesis are not well understood. MMPs mainly promote ECM, promote cell apoptosis, affect angiogenesis and promote the release of cytokines Pathways involved in the occurrence and development of IBD and its complications. To strengthen the study of MMPs / TIMPs is conducive to further explore the pathogenesis of IBD, to explore new treatment methods is of great significance.