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乳铁蛋白是具有广泛生物学功能的蛋白类治疗药物,直接通过口服乳铁蛋白给药虽然便捷,但蛋白类药物从消化系统进入血液循环需要克服大量障碍,而壳聚糖作为负载蛋白类药物载体在保持自身缓释特性的同时,还可以保护对环境敏感的蛋白类药物免受降解,因而是载药微粒的理想组合,针对壳聚糖负载乳铁蛋白类微粒制备的研究情况进行综述。
Lactoferrin is a proteinaceous therapeutic drug with a broad range of biological functions. Direct administration of lactoferrin via oral administration, although convenient, requires a great deal of hurdles to be overcome by the entry of protein drugs into the bloodstream from the digestive system. Chitosan, as a loaded protein drug The carrier can protect the environment-sensitive proteinaceous medicine from being degraded while maintaining its sustained-release properties. Therefore, the carrier is an ideal combination of drug-loaded particles, and the research on the preparation of chitosan-loaded lactoferrin particles is reviewed.