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从麝Moschus moscmiferus L.的香囊中的干燥分泌物(即麝香)中分离得到Musclide-A(6-甲基-2,5-庚二醇一5-(硫酸氢盐))。水溶性提取物Musclide(浓度为100μg/ml)和Musclide-A_1(浓度为30μg/ml)作用于豚鼠乳头肌时,能够加强β-肾上腺素能的强心作用。Musclide—A_1(浓度为130μmol/L)或者1,2-二辛酰丙三醇(浓度为200μmol/L)可以强化由最大浓度的异丙去甲肾上腺素(258nmol/L)诱导的正性肌力作用。该强化作用可被3n-mol/L的staurosporine或者1μmol/L的H-7(一种依赖于钙离子的蛋白质激酶的抑制剂)
Musclide-A (6-methyl-2,5-heptanediol-5- (bisulfate)) was isolated from the dry exudate (ie musk) in the sachet of Moschus moscmiferus L. Water-soluble extracts of Musclide (at a concentration of 100 μg / ml) and Musclide-A_1 (at a concentration of 30 μg / ml) enhanced the cardioprotective effect of β-adrenergic in guinea pig papillary muscles. Musclide-A 1 (at a concentration of 130 μmol / L) or 1,2-dioctanoylglycerol (at a concentration of 200 μmol / L) potentiated the positive myocytes induced by maximal concentrations of allopurinol (258 nmol / L) Force effect. This potentiation can be induced by 3n-mol / L staurosporine or 1 mol / L H-7, an inhibitor of a calcium-dependent protein kinase,