目的了解浙江省宁波市人类免疫缺陷病毒(HIV)感染者的梅毒感染情况及其影响因素,为采取相应的干预措施提供参考依据。方法收集2015年5月—2015年12月宁波市艾滋病自愿咨询检测(VCT)门诊和艾滋病专项管理软件登记在册的2 090例HIV感染者的临床病历资料,分析宁波市HIV感染者的梅毒患病情况及其相关影响因素。结果宁波市2 090例HIV感染者中感染梅毒者197例,梅毒感染率为9.4%;多因素非条件logistic回归分析结果显示,年龄≥46岁和性伴数量≥2个是宁波市HIV感染者梅毒感染的危险因素,女性、文化程度初中及以上和采用高效抗逆转录病毒疗法(HAART)治疗是宁波市HIV感染者梅毒感染的保护因素。结论宁波市HIV感染者梅毒患病率较高,性别、年龄、文化程度、性伴数量和是否采用HAART治疗是宁波市HIV感染者梅毒感染的主要影响因素。 Objective To understand the prevalence and influencing factors of syphilis infection in people living with HIV in Ningbo City, Zhejiang Province, and to provide a reference for taking corresponding interventions. Methods The clinical records of 2 090 HIV-infected individuals registered in Ningbo City from May 2015 to December 2015 were collected. The prevalence of syphilis among HIV-infected persons in Ningbo City was analyzed. The situation and its related factors. Results Ninety-seven cases of syphilis were detected in 2 090 HIV-infected persons in Ningbo City, and the syphilis infection rate was 9.4%. Multivariate non-conditional logistic regression analysis showed that those aged ≥46 years and sexual partners ≥2 were infected with HIV in Ningbo The risk factors of syphilis infection, female, junior high school education and above, and the treatment with highly effective antiretroviral therapy (HAART) are the protective factors of syphilis infection in HIV-infected persons in Ningbo City. Conclusion The prevalence of syphilis in HIV-infected persons in Ningbo City is relatively high. Sex, age, educational level, number of sexual partners and HAART treatment are the main influencing factors of syphilis infection in HIV-infected patients in Ningbo.