目的 :探讨吡喃阿霉素 (THP)与大剂量碘油肝动脉栓塞化疗治疗不能手术切除原发性肝癌的方法和疗效。方法 :经皮肝动脉栓塞化疗 ,治疗组 146例 ,注入单次剂量为 6 0mg吡喃阿霉素和 2 0～ 6 0ml超化碘油 (Lipiodol)混悬液 ;对照组 188例 ,用 6 0mg表阿霉素和 5～ 19ml超化碘油。结果 :术后副作用不大 ,未见严重并发症。治疗组146例的 1、2、3年生存率为 71.2 %、39.4%、2 7.1% ;对照组 188例分别为 49.5 %、2 7.7%、2 0 .3% (P =0 .0 342 )。结论 :对ChildA级和ICGR 15小于 2 0 %的富血管型肝癌 ,THP与大剂量的碘油联合用药 ,绝大多数患者能够耐受 ,不会出现严重的并发症 ,且疗效优于常规的栓塞化疗 Objective: To explore the method and efficacy of pirarubicin (THP) and large dose lipiodol hepatic artery embolization chemotherapy for the treatment of primary hepatocellular carcinoma. Methods: Percutaneous transcatheter arterial chemoembolization was performed in 146 patients in the treatment group. A single dose of 600 mg of pirarubicin and 20-60 ml of Lipiodol suspension was administered; 188 patients in the control group were treated with 6 0 mg epirubicin and 5 to 19 ml of lipiodol. Results: There were no serious side effects and no serious complications. The 1-, 2-, and 3-year survival rates of the 146 patients in the treatment group were 71.2%, 39.4%, and 27.1%; those in the control group were 49.5 %, 27.7%, and 20.3% (P=0.0402). . Conclusion: For Child A grade and ICGR 15 less than 20% of angiogenic liver cancer, THP is combined with large doses of lipiodol, most patients can tolerate, without serious complications, and the efficacy is superior to conventional Embolization Chemotherapy