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在生物体内,蛋白质翻译后修饰具有十分重要的作用,ADP-核糖基化和泛素化修饰作为2个重要的蛋白翻译后修饰类型,参与重要的生命活动。ADP-核糖基化在维持基因组的稳定性,转录调节、细胞分化与信号转导、肿瘤的发生发展等重要的生命活动相关。泛素化在蛋白质定位、代谢、功能、调节和降解中发挥重要作用,几乎参与一切生命活动的调控。蛋白翻译后修饰过程不是孤立存在的,同一生理或病理过程的发
In vivo, protein post-translational modification has a very important role, ADP-ribosylation and ubiquitination modification as two important types of protein post-translational modification, involved in important life activities. ADP-ribosylation is associated with the maintenance of important life events such as genome stability, transcriptional regulation, cell differentiation and signal transduction, and the development of tumors. Ubiquitination plays an important role in protein localization, metabolism, function, regulation and degradation, and it participates almost in the regulation of all life activities. The process of protein post-translational modification is not isolated, with the same physiological or pathological process