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肥胖是形成Ⅱ型糖尿病和心血管疾病的重要风险因子.Wnt信号通路是调控多个细胞发育与分化的重要信号因子.本研究介绍了脂肪组织结构、脂肪细胞分化的调控因子、经典和非经典Wnt信号通路.从肥胖与糖尿病的临床观察、脂肪分化与发育、线粒体代谢与炎症反应的角度,阐述了经典和非经典Wnt信号通路对脂肪发育和代谢的影响.
Obesity is an important risk factor for the formation of type 2 diabetes mellitus and cardiovascular diseases.Wnt signaling pathway is an important signal factor that regulates the development and differentiation of multiple cells.This study introduced the regulation of adipose tissue structure, adipocyte differentiation, classical and non-classical Wnt signaling pathway.The effects of both classical and non-canonical Wnt signaling pathways on fat development and metabolism are elucidated from the perspective of clinical observations of obesity and diabetes, differentiation and development of fat, mitochondrial metabolism and inflammatory responses.