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毛冬青(llex Pubeseens Hook et Arn)为民间广泛应用的活血通脉,消肿止痛,清热解毒药。毛冬青甲素系从毛冬青中提取的一种有效成分,经化学半合成而制成。经药理实验证明有抗大白鼠实验性血栓形成、缩小大鼠心肌梗塞范围、保护豚鼠心肌急性缺血等作用。临床观察刘冠心病、心肌梗塞、脑血栓有明显的疗效。为了进一步阐明毛冬青甲素的抗血栓性疾病的作用机制,本试验用兔研究了毛冬青甲素在体内及体外对血小板生成血小板(口恶) A_2(TXA_2的)影响。
Illex Pubeseens Hook et Arn is widely used by the general public to promote blood circulation, reduce swelling, relieve pain, and clear away heat and detoxify drugs. Mao Dong Qing Jia Su is an effective ingredient extracted from Mao Dongqing and is made by chemical semi-synthesis. The pharmacological experiments have shown that there are antithrombotic effects in rats, the reduction of myocardial infarction in rats, and the protection of acute myocardial ischemia in guinea pigs. Clinical observation of coronary heart disease, myocardial infarction, cerebral thrombosis has obvious curative effect. In order to further elucidate the mechanism of action of anti-thrombotic diseases of scopolamine, the effects of hollycumber on the production of platelet platelet (poisonous) A_2 (TXA_2) in vitro and in vivo were studied in rabbits.