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联合使用GHRH、TRH、LHRH和CRH四种下丘脑释放激素检查6例正常青少年和50例未治疗IGHD患者血PRL、TSH、LH及F的反应,并从基础值、峰值、峰值增加值、峰值/基础值比值、激素反应曲线下面积和阳性反应率等六个方面比较两组结果。IGHD患者血PRL、TSH及F六项指标的反应与对照组比较差异无显著性,表明IGHD患者垂体PRL、TSH及ACTH细胞的储备功能正常。约2/3IGHD患者LH细胞的储备功能低下。在青春发育年龄的IGHD患者LH对LHRH的反应除峰值/基础值比值以外,另五项指标均非常明显低于对照组(P<0.001),这可能是成年IGHD患者性发育延迟及差的原因。
The combined use of GHRH, TRH, LHRH and CRH four kinds of hypothalamic hormone release test 6 cases of normal adolescents and 50 cases of untreated IGHD patients with PRL, TSH, LH and F response, and from the basic value, peak, peak value added, peak / Basal ratio, the area under the hormone response curve and the positive response rate of six groups compared the results of two groups. There was no significant difference in the response of six indicators of PRL, TSH and F in patients with IGHD compared with the control group, indicating that the reserve function of PRL, TSH and ACTH cells in pituitary of IGHD patients is normal. About 2 / 3IGHD LH cells in patients with reserve function is low. In addition to the peak / basal ratio of LH response to LHRH in adolescents with IGHD, the other five indicators were significantly lower than those in the control group (P <0.001), which may be the reason for delayed sexual development and poor outcome in adult patients with IGHD .