髂内动脉灌注化疗在进展期直肠癌患者中的应用

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目的研究手术前后经髂内动脉灌注化疗对进展期直肠癌的意义。方法 26例进展期直肠癌患者,随机分为实验组(n=13),对照组(n=13),对照组术前经髂内动脉置管进行区域化疗2~3个疗程,术后继续进行髂内动脉灌注化疗。并在术前化疗结束后和手术中对术前化疗疗效进行评价,并观察其近期及远期生存率。结果术前化疗结束后,肿瘤浸润深度,肿瘤直径,淋巴结受累情况均较化疗前有明显改善,手术切除率提高,手术范围减小。近期及远期生存率均较对照组提高(P<0.05)。结论术前经髂内动脉灌注化疗明显的对进展期直肠癌进行了降期,提高了手术切除率,并且使术后复发,转移的发生率降低,生存率明显提高。 Objective To study the significance of chemotherapy of internal iliac artery before and after surgery on advanced colorectal cancer. Methods Twenty-six patients with advanced colorectal cancer were randomly divided into experimental group (n = 13) and control group (n = 13). The control group received 2 ~ 3 cycles of regional chemotherapy before the internal iliac artery catheterization. Internal iliac artery infusion chemotherapy. The effect of preoperative chemotherapy was evaluated after preoperative chemotherapy and surgery, and the short-term and long-term survival rates were observed. Results After the preoperative chemotherapy, the depth of tumor invasion, tumor diameter and lymph node involvement were significantly improved compared with that before chemotherapy. Surgical resection rate increased and the scope of surgery decreased. The short-term and long-term survival rates were higher than those in the control group (P <0.05). Conclusion Intra-iliac arterial infusion chemotherapy significantly reduces the progression of advanced rectal cancer, increases the resection rate, and reduces the incidence of postoperative recurrence and metastasis, and significantly improves the survival rate.
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