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目的:探讨合理选择孕妇梅毒血清学筛查的有效方法,提高筛查的敏感性和特异性。方法:对11276例孕妇同时采用甲苯胺红不加热血清试验(TRUST)、梅毒螺旋体抗体酶联免疫吸附试验(TP-ELISA)进行梅毒血清学检测,阳性标本采用梅毒螺旋体明胶凝集试验(TPPA)进行确证,对检测结果进行比较分析。结果:11276例孕妇中TRUST阳性28例,占受检总数0.25%;TP-ELISA阳性76例,占受检总数0.67%;TPPA阳性74例,占受检总数0.66%,TRUST、TP-ELISA、TPPA三种检测方法均阳性占0.25%。结论:对于首次进行孕检的人群,宜选用TP-ELISA进行筛查,提高初检结果的检出率和可靠性,做到早发现、早诊断、早治疗。TP-ELISA阳性标本以TPPA确诊,TPPA确诊标本再查TRUST滴度试验,以便于观察疗效、判断复发及再感染,提高遗传优生率。
Objective: To explore a reasonable method of serological screening of pregnant women with syphilis and to improve the sensitivity and specificity of screening. Methods: Twelve hundred and seventy-seven pregnant women were tested for syphilis serology by TRUST and TP-ELISA, and the positive specimens were treated with TPPA (Treponema Pallidum Gelatin Agglutination Test) Confirmation, comparative analysis of test results. Results: The number of TRUST positive in 11276 pregnant women was 28, accounting for 0.25% of the total; the positive rate of TP-ELISA was 76, accounting for 0.67% of the total; the number of positive TPPA was 74, accounting for 0.66% TPPA three detection methods were positive accounted for 0.25%. Conclusion: For the first pregnancy test, TP-ELISA should be used for screening to improve the detection rate and reliability of the initial examination results, so that early detection, early diagnosis and early treatment can be achieved. TP-ELISA positive specimens were diagnosed by TPPA, TPPA confirmed specimens TRUST titer test again in order to observe the curative effect, to determine the recurrence and re-infection, improve genetic eugenics rate.