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分析报告 1例大疱性系统性红斑狼疮。患者以全身皮肤粘膜起红斑、水疱为表现起病 ,伴有口腔溃疡、双膝关节疼痛 ,尿蛋白 3 +,ANA阳性 1∶1 60颗粒型 ,ds DNA抗体阳性 ,ENA阳性、SS A阳性。取躯干部皮损行组织病理活检 ,HE染色示 :表皮下水疱 ,真皮浅层水肿 ,真皮乳头见中性粒细胞聚集 ,免疫病理示基底膜带可见IgG呈颗粒状沉积 ,符合大疱性系统性红斑狼疮病理改变。该病例为大疱性系统性红斑狼疮
Analysis of 1 case of bullous systemic lupus erythematosus. Patients with systemic skin and mucous membrane erythema, vesicular manifestations of onset, accompanied by oral ulcers, knee pain, urinary protein 3, ANA positive 1:160 particles, ds DNA antibody positive, ENA positive, SS A positive. Tissue and pathological biopsy were taken from the skin lesions of the trunk. HE staining showed epidermal vesicles, superficial dermal edema and neutrophil accumulation in the dermal papillae. Immunohistochemistry revealed basal membrane with IgG particles grainy deposition, consistent with the bullous system Pathological changes of lupus erythematosus. This case is bullous systemic lupus erythematosus