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以离体培养HeLa细胞存活曲线研究了S-8712对乏氧细胞放射增敏效果。实验结果表明浓度为2m mol/L时,以D_0和D_q分别计算所得增敏比(SER)为1.04和1.26。6m mol/L的SER则分别为1.35和1.25。该化合物对有氧细胞的亚致死损伤修复有抑制作用,但对有氧细胞放射敏感性没有影响。
The radiosensitizing effect of S-8712 on hypoxic cells was studied by the survival curve of in vitro cultured HeLa cells. The experimental results show that when the concentration is 2m mol/L, the sensitized ratio (SER) calculated by D_0 and D_q is 1.04 and 1.26, respectively. The SER of 6m mol/L is 1.35 and 1.25, respectively. The compound has an inhibitory effect on the repair of sublethal damage of aerobic cells, but has no effect on the radiosensitivity of aerobic cells.