Statistically,85% of active pharmaceutical ingredients (APIs) exhibit polymorphism or solvato-morphism and 50% of APIs have multiple polymorphs or solvates/
In the last 10-15 years,after an implementation of the ICH-E9 guideline entitled "Statistical Principles for Clinical Trials",there has been an increasing a
Tadalafil is a phosphodiesterase-5 inhibitor.It has the disadvantage of poor aqueous solubility.Therefore,it is important to develop an effective method to