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病人和方法本文为瑞典东南部8间医院的一项前瞻性、随机、双盲、安慰剂对照的多中心研究。最初旨在探讨口服阿司匹林75mg/d 长达1年和/或在最初5天静脉给予肝素,在不稳定型冠心病(CAD)发作后对心肌梗塞(MI)的发生率和死亡率的影响。不稳定型 CAD 的定义为非 Q 波型 MI 或在近4周内心绞痛的发作增加,且在休息时或在负荷运动试验的心电图有心肌缺血表现。入选病人年龄均在70岁以下。静脉间歇给予肝素或生理盐水:在头24小时内给予浓度为5000IU/ml 的肝素,每6小时给2ml;接着每6小时1.5ml 共4天。同时开始口服75mg 阿司匹林或安慰剂,持续1年。没有治疗禁忌症的全部患者口
PATIENTS AND METHODS This is a prospective, randomized, double-blind, placebo-controlled, multicenter study of 8 hospitals in southeastern Sweden. Initially intended to investigate the effect of intravenous aspirin 75 mg / d up to 1 year and / or intravenous heparin intravenously during the first 5 days on the incidence and mortality of myocardial infarction (MI) following an episode of unstable coronary artery disease (CAD). Unstable CAD is defined as either non-Q-wave MI or an increase in angina pectoris within the last 4 weeks, with myocardial ischemia at rest or during the electrocardiogram of the stress exercise test. The selected patients are under 70 years of age. Intravenous administration of heparin or saline: heparin at a concentration of 5000 IU / ml for the first 24 hours, 2 ml every 6 hours; followed by 1.5 ml every 6 hours for 4 days. At the same time, 75 mg of aspirin or placebo should be given orally for 1 year. No treatment of contraindications in all patients mouth