Objective: To quantitatively study basic fibroblast growth factor (bFGF) in the vitreous of proliferative vitreoretinopathy (PVR) in order to understand the role ofbFGF in the development of PVR.rnMethod: High sensitive sandwich enzyme immunoassay technique (ELISA) was used to measure bFGF level in vitreous of normal eyes, the eyes of PVR-C or PVR-D grade,eyes of vitreous hemorrhage and the serum levels of bFGF in PVR-D patients.rnResults: The levels of bFGF in the vitreous were: median 5.20ng/L, quartile 15.47ng/L in 20 normal eyes; median 3.12ng/L, quartile 10.48 ng/L in 35 PVR-C eyes;median 46.56 ng/L, quartile 113.96 ng/L in 26 PVR-D eyes; median 1.40 ng/L, quartile 6. 25 ng/L in 25 vitreous hemorrhage eyes. The vitreous bFGF level in PVR-D group was significantly higher than that in the normal group, PVR-C group and vitreous hemorrhage group ( P ＜ 0. 01 ). The mean of serum-bFGF level was 18.33 ± 3.39 ng/L. The vitreous bFGF level of PVR-D group was significantly higher than serum-bFGF level( P ＜ 0. 01 ). And the vitreous-bFGF level in PVR-D group was significantly higher in larger retinal tear subgroup.rnConclusion: The results suggested that bFGF is involved in the development of PVR.Eye Science 2000; 16:7 ～ 10.