胆红素不只是体内的代谢产物,它还具有抗氧化、抗脂质过氧化、抗炎、抑制细胞凋亡等作用。核因子κB(NF-κB)作为一种普遍存在的转录因子,参与多种信号转导途径,可高效诱导多种细胞因子,同时对参与炎性反应放大与延续的多种酶的基因表达也具有重要的调控作用。本文就胆红素与NF-κB关系进行综述。 Bilirubin is not only the body’s metabolites, it also has antioxidant, anti-lipid peroxidation, anti-inflammatory, inhibition of apoptosis and other effects. As a ubiquitous transcription factor, nuclear factor-kappa B (NF-κB) is involved in many signal transduction pathways and induces a variety of cytokines efficiently. At the same time, NF-κB is also involved in the gene expression of various enzymes involved in the amplification and continuation of inflammatory responses Has an important regulatory role. This article reviews the relationship between bilirubin and NF-κB.